Predictors of intestinal inflammation in asymptomatic first-degree relatives of patients with Crohn's disease
نویسندگان
چکیده
1. Department of Medical and Molecular Genetics, Kings College London, Guy’s Hospital, London, United Kingdom 2. Department of Clinical Neurosciences, University of Cambridge, Cambridge, United Kingdom 3. Sydney Brenner Institute for Molecular Bioscience, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa 4. Department of Gastroenterology, Guy’s & St Thomas’ NHS Foundation Trust, St Thomas’ Hospital, London, United Kingdom 5. Department of Gastroenterology, Southampton General Hospital, Southampton, United Kingdom
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Intestinal permeability in patients with Crohn's disease.
Increased intestinal permeability in patients with Crohn's disease and their first degree relatives has been proposed as an aetiological factor. The nine hour overnight urinary excretion of polyethyleneglycol-400 (PEG-400) and three inert sugars (lactulose, l-rhamnose, and mannitol) was used to test the permeation in 47 patients with Crohn's disease of whom 18 had at least one first degree rela...
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